KNU Alzheimer’s disease Research Institute

2020
  • Lee JY, Han SH, Park MH, Song IS, Choi MK, Yu ES, Park CM, Kim HJ, Kim SH, Edward H. Schuchcman, Jin HK, Bae JS. N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease. Nat Commun, 2020 May 12. doi: 10.1038/s41467-020-16080-4
  • Park MH, Jin HK, Bae JS. Potential Therapeutic Target for Aging and Age-Related Neurodegenerative Diseases: The Role of Acid Sphingomyelinase. Exp Mol Med. 2020 Mar;52(3):380-389.
  • Kim YM, Yum MS, Heo SH, Kim T, Jin HK, Bae JS, Seo GH, Oh A, Yoon HM, Lim HT, Kim HW, Ko TS, Lim HS, Osborn MJ, Tolar J, Cozma C, Rolfs A, Zimran A, Lee BH, Yoo HW. Pharmacologic Properties of High-Dose Ambroxol in Four Patients With Gaucher Disease and Myoclonic Epilepsy. J Med Genet. 2020 Feb;57(2):124-131.
  • Lee JY, Jin HK, Bae JS. Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy. BMB Rep. 2020 Jan;53(1):28-34.
2019
  • Park MH, Lee MS, Nam GW, Kim MG, Kang JH, Choi BJ, Jeong MS, Park KH, Han WH, Tak EY, Kim MS, Lee JR, Lin YX, Lee YH, Song IS, Choi MK, Lee JY, Jin HK, Bae JS, Lim MH. N,N'-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer's disease transgenic mice. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23426-23436.
  • Kim YM, Yum MS, Heo SH, Kim T, Jin HK, Bae JS, Seo GH, Oh A, Yoon HM, Lim HT, Kim HW, Ko TS, Lim HS, Osborn MJ, Tolar J, Cozma C, Rolfs A, Zimran A, Lee BH, Yoo HW. Pharmacologic properties of high-dose ambroxol in four patients with Gaucher disease and myoclonic epilepsy. J Med Genet. 2019 Oct 24.
  • Jeong MS, Bae JS, Jin HK. Vascular endothelial growth factor improves the therapeutic effects of cyclodextrin in Niemann-Pick type C mice. Anim Cells Syst (Seoul). 2019 Aug 25;23(5):346-354.
  • Park MH, Choi BJ, Jeong MS, Lee JY, Jung IK, Park KH, Lee HW, Yamaguchi T, Marti HH, Lee BH, Schuchman EH, Jin HK, Bae JS. Characterization of the Subventricular-Thalamo-Cortical Circuit in the NP-C Mouse Brain, and New Insights Regarding Treatment. Mol Ther. 2019 Aug 7;27(8):1507-1526.
  • Kim SH, Noh MY, Kim HJ, Oh KW, Park J, Lee S, Moon Y, Kim YE, Bae JS, Jin HK. A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation. Dement Neurocogn Disord. 2019 Jun;18(2):33-46.
  • Yi Y, Han J , Park MH , Park N , Nam E , Jin HK , Bae JS , Lim MH. Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)-amyloid-β. Chem Commun (Camb). 2019 May 21;55(42):5847-5850.
  • Lee JS, Eo P. Kim MC, Kim JB, Jin HK, Bae JS, Jeong JH, Park HY, Yang J. Effects of Stromal Vascular Fraction on Breast Cancer Growth and Fat Engraftment in NOD/SCID Mice. Aesthetic Plast Surg 2019 Apr;43(2):498-513.
  • Park MH, Jin HK, Bae JS. Acid sphingomyelinase-mediated blood-brain barrier disruption in aging. BMB Rep. 2019 Feb;52(2):111-112.
2018
  • Kim SH, Oh KW, Jin HK, Bae JS. Immune inflammatory modulation as a potential therapeutic strategy of stem cell therapy for ALS and neurodegenerative diseases. BMB Rep. 2018 Nov;51(11):545-546.
  • Park MH, Lee JY, Park KH, Jung IK, Kim KT, Lee YS, Ryu HH, Jeong Y, Kang MS, Schwaninger M, Gulbins E, Reichel M, Kornhuber J, Yamaguchi T, Kim HJ, Kim SH, Schuchman EH, Jin HK, Bae JS. Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM. Neuron. 2018 Oct 10;100(1):167-182.
  • Kim JA, Choi HJ, Kim CM, Jin HK, Bae JS, Kim GM. Enhancement of Virus Infection Using Dynamic Cell Culture in a Microchannel. Micromachines. 2018 Sep 21;9(10).
  • Park MH, Baek B, Jin HK, Bae JS. Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment. Animal Cells Syst. 2018 Sep 5;22(5):281-288.
  • Kim JB, Jeon HJ, Lee JW, Choi KY, Chung HY, Cho BC, Park SH, Park MH, Bae JS, Yang JD. A murine model of radiation-induced capsule-tissue reactions around smooth silicone implants. J Plast Surg Hand Surg. 2018 Aug;52(4):217-224.
  • Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS , Jin HK. Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
    Nat Commun . 2018 Apr 16;9(1):1479.
  • Park MH, Lee JY, Jeong MS, Jang HS, Endo S, Bae JS, Jin HK. The role of Purkinje cell-derived VEGF in cerebellar astrogliosis in Niemann-Pick type C mice. BMB Rep. 2018 Feb;51(2):79-84.
  • Choi JH, Jin HK, Bae JS, Kim GM. Fabrication of Three-Dimensional Complex Shape PDMS Microstencil Using Air-Knife System and their Cell Culture Application. J Korean Soc Precis Eng. 2018;35(1);111-115
2017
  • Kavitha MS, Kurita T, Park SY, Chien SI, Bae JS, Ahn BC. Deep vector-based convolutional neural network approach for automatic recognition of colonies of induced pluripotent stem cells. PLoS One. 2017 Dec 27;12(12):e0189974
  • Park MH, Jung IK, Min WK, Choi JH, Kim GM, Jin HK, Bae JS. Neuropeptide Y improves cisplatin-induced bone marrow dysfunction without blocking chemotherapeutic efficacy in a cancer mouse model. BMB Rep. 2017 Aug;50(8):417-422.
  • Park MH, Kim N, Jin HK, Bae JS. Neuropeptide Y-based recombinant peptides ameliorate bone loss in mice by regulating hematopoietic stem/progenitor cell mobilization. BMB Rep. 2017 Mar;50(3):138-143.
2016
  • Lee H, Kim GM, Choi JH, Park MH, Bae JS, Jin HK. Highly efficient reprogramming and characterization of induced pluripotent stem cells by using a microwell array. Tissue Eng Regen Med 2016 Dec;13(6):691-700.
  • Klionsky DJ, Bae JS et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222.
  • Lee JK, Wang K, Park MH, Kim N, Lee JY, Jin HK, Kim IS, Lee BH, Bae JS. Probing amyloid beta-induced cell death using a fluorescence-peptide conjugate in Alzheimer's disease mouse model. Brain Res. 2016 Sep 1;1646:514-21
  • Park MH, Lee JK, Kim N, Min WK, Lee JE, Kim KT, Akiyama H, Herzog H, Schuchman EH, Jin HK, Bae JS. Neuropeptide Y induces hematopoietic stem/progenitor cell mobilization by regulating matrix metalloproteinase-9 activity through Y1 receptor in osteoblasts. Stem Cells. 2016 Aug;34(8):2145-56
  • Lee SY, Lee HJ, Kim SH, Jeong YJ, Jin HK, Bae JS, Cheon SM, Kim JW. Two Siblings with Adolescent/Adult Onset Niemann-Pick Disease Type C in Korea. J Korean Med Sci. 2016 Jul;31(7):1168-72.
  • Kim N, Min WK, Park MH, Lee JK, Jin HK, Bae JS. Neuropeptide Y protects cisplatin-induced nephrotoxicity by regulating the p53-dependent apoptosis pathway. BMB Rep. 2016 May;49(5):288-92
  • Choi JH, Bae JS, Lee H, Jin HK, Kim GM. Micropatterned Culture and Differentiation of Human Bone Marrow Mesenchymal Stem Cells Using a Polydimethylsiloxane Microstencil. J Biomed Nanotechnol. 2016 Feb;12(2):366-70.
2015
  • Lee JK, Jin HK, Bae JS. ASM in Alzheimer's disease. Oncotarget. 2015 Nov 24;6(37):39389-90
  • Park MH, Min WK, Jin HK, Bae JS. Role of Neuropeptide Y in the bone marrow hematopoietic stem cell microenvironment. BMB Rep. 2015 Dec;48(12):645-6
  • Lee H, Bae JS, Jin HK. Defective Self-Renewal and Differentiation of GBA-Deficient Neural Stem Cells Can Be Restored By Macrophage Colony-Stimulating Factor. Mol Cells. 2015 Sep 30;38(9):806-13
  • Kim KT, Kim HJ, Cho DC, Bae JS, Park SW. Substance P stimulates proliferation of spinal neural stem cells in spinal cord injury via the mitogen-activated protein kinase signaling pathway. Spine J. 2015 Sep 1;15(9):2055-65.
  • Park MH, Jin HK, Min WK, Lee WW, Lee JE, Akiyama H, Herzog H, Enikolopov GN, Schuchman EH, Bae JS. Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow. EMBO J. 2015 Jun 12;34(12):1648-60
  • Hong YR, Lee H, Park MH, Lee JK, Lee JY, Suh HD, Jeong MS, Bae JS, Jin HK. CCL2 induces neural stem cell proliferation and neuronal differentiation in Niemann-Pick type C mice. J Vet Med Sci. 2015 Jun;77(6):693-9.
  • Lee H, Kim GM, Choi JH, Lee JK, Bae JS, Jin HK. Highly reproducible quantification of apoptotic cells using micropatterned culture of neurons. Anal Biochem. 2015 Jan 15;469:65-70.
2014
  • Lee H, Lee JK, Park MH, Hong YR, Marti HH, Kim H, Okada Y, Otsu M, Seo EJ, Park JH, Bae JH, Okino N, He X, Schuchman EH, Bae JS, Jin HK. Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons. Nat Commun. 2014 Nov 24;5:5514.
  • Chun SY, Kwon JB, Chae SY, Lee JK, Bae JS, Kim BS, Kim HT, Yoo ES, Lim JO, Yoo JJ, Kim WJ, Kim BW, Kwon TG. Combined injection of three different lineages of early-differentiating human amniotic fluid-derived cells restores urethral sphincter function in urinary incontinence. BJU Int. 2014 Nov;114(5):770-83.
  • Im JY, Min WK, Park MH, Kim N, Lee JK, Jin HK, Choi JY, Kim SY, Bae JS. AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells. BMB Rep. 2014 Aug;47(8):439-44.
  • Lee JK, Jin HK, Park MH, Kim BR, Lee PH, Nakauchi H, Carter JE, He X, Schuchman EH, Bae JS. Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease. J Exp Med. 2014 Jul 28;211(8):1551-70.
  • Son S, Kim KT, Cho DC, Kim HJ, Sung JK, Bae JS. Curcumin Stimulates Proliferation of Spinal Cord Neural Progenitor Cells via a Mitogen-Activated Protein Kinase Signaling Pathway. J Korean Neurosurg Soc. 2014 Jul;56(1):1-4.
  • Choi JH, Jin HK, Bae JS, Park CW, Cheong IW, Kim GM. Fabrication of detachable hydrogel microplates for separably patterned cell culture. Int J Precis Eng Man. 2014 May;15(5):945-948.
  • Lee H, Lee JK, Bae YC, Yang SH, Okino N, Schuchman EH, Yamashita T, Bae JS, Jin HK. Inhibition of GM3 synthase attenuates neuropathology of niemann-pick disease type C by affecting sphingolipid metabolism. Mol Cells. 2014 Feb;37(2):161-71.
  • Shin JY, Park HJ, Kim HN, Oh SH, Bae JS, Ha HJ, Lee PH. Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models. Autophagy. 2014 Jan;10(1):32-44.
2013
  • Im JY, Min WK, You C, Kim HO, Jin HK, Bae JS. Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cells in scaffold. Lab Anim Res. 2013 Dec;29(4):196-203.
  • Kim BJ, Lee JK, Schuchman EH, Jin HK, Bae JS. Synergistic vasculogenic effects of AMD3100 and stromal-cell-derived factor-1α in vasa nervorum of the sciatic nerve of mice with diabetic peripheral neuropathy. Cell Tissue Res. 2013 Nov;354(2):395-407.
  • Park MH, Lee JK, Choi S, Ahn J, Jin HK, Park JS, Bae JS. Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice. Brain Res. 2013 Sep 5;1529:113-24.
  • Lee H, Kang JE, Lee JK, Bae JS, Jin HK. Bone-marrow-derived mesenchymal stem cells promote proliferation and neuronal differentiation of Niemann-Pick type C mouse neural stem cells by upregulation and secretion of CCL2. Hum Gene Ther. 2013 Jul;24(7):655-69.
  • Bae JS, Jin HK, Lee JK, Richardson JC, Carter JE. Bone marrow-derived mesenchymal stem cells contribute to the reduction of amyloid-β deposits and the improvement of synaptic transmission in a mouse model of pre-dementia Alzheimer's disease. Curr Alzheimer Res. 2013 Jun;10(5):524-31.
  • Choi JH, Lee H, Jin HK, Bae JS, Kim GM. Fabrication of microengineered templates and their applications into micropatterned cell culture. J Biomed Nanotechnol. 2013 Mar;9(3):377-81.
2012
  • Choi JH, Lee H, Jin HK, Bae JS, Kim GM. Micropatterning of neural stem cells and Purkinje neurons using a polydimethylsiloxane (PDMS) stencil. Lab Chip. 2012 Dec 7;12(23):5045-50.
  • Kim BS, Chun SY, Lee JK, Lim HJ, Bae JS, Chung HY, Atala A, Soker S, Yoo JJ, Kwon TG. Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model. BMC Med. 2012 Aug 21;10:94.
  • Lee JK, Chun SY, Im JY, Jin HK, Kwon TG, Bae JS. Specific labeling of neurogenic, endothelial, and myogenic differentiated cells derived from human amniotic fluid stem cells with silica-coated magnetic nanoparticles. J Vet Med Sci. 2012 Aug;74(8):969-75.
  • Lee JK, Schuchman EH, Jin HK, Bae JS. Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses. Stem Cells. 2012 Jul;30(7):1544-55.
  • Park CW, Lee C, Lim S, Ni A, An JH, Lee H, Bae JS, Kim J Investigation of the performance of spectral domain optical doppler tomography with high-speed line scanning CMOS camera and its application to the blood flow measurement in a micro-tube. J. Opt. Soc. Korea. 2012 Jun;16(2):174-180.
  • Lee HJ, Lee JK, Lee H, Carter JE, Chang JW, Oh W, Yang YS, Suh JG, Lee BH, Jin HK, Bae JS. Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation. Neurobiol Aging. 2012 Mar;33(3):588-602.
2011
  • Shin JW, Lee JK, Lee JE, Min WK, Schuchman EH, Jin HK, Bae JS. Combined effects of hematopoietic progenitor cell mobilization from bone marrow by granulocyte colony stimulating factor and AMD3100 and chemotaxis into the brain using stromal cell-derived factor-1α in an Alzheimer's disease mouse model. Stem Cells. 2011 Jul;29(7):1075-89.
  • Kim BJ, Jin HK, Bae JS. Bone marrow-derived mesenchymal stem cells improve the functioning of neurotrophic factors in a mouse model of diabetic neuropathy. Lab Anim Res. 2011 Jun;27(2):171-6.
  • Min WK, Lee HJ, Jeong WJ, Oh CW, Bae JS, Cho HS, Jeon IH, Cho CH, Park BC. Reliability of Triggered EMG for Prediction of Safety during Pedicle Screw Placement in Adolescent Idiopathic Scoliosis Surgery. Asian Spine J. 2011 Mar;5(1):51-8.
2010
  • Min WK, Bae JS, Park BC, Jeon IH, Jin HK, Son MJ, Park EK, Kim SY. Proliferation and osteoblastic differentiation of bone marrow stem cells: comparison of vertebral body and iliac crest. Eur Spine J. 2010 Oct;19(10):1753-60.
  • Singh TD, Park SY, Bae JS, Yun Y, Bae YC, Park RW, Kim IS. MEGF10 functions as a receptor for the uptake of amyloid-β. FEBS Lett. 2010 Sep 24;584(18):3936-42.
  • Lee HJ, Lee JK, Lee H, Shin JW, Carter JE, Sakamoto T, Jin HK, Bae JS. The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease. Neurosci Lett. 2010 Aug 30;481(1):30-5.
  • Lee JM, Bae JS, Jin HK. Intracerebellar transplantation of neural stem cells into mice with neurodegeneration improves neuronal networks with functional synaptic transmission. J Vet Med Sci. 2010 Aug;72(8):999-1009.
  • Lee JK, Jin HK, Bae JS. Bone marrow-derived mesenchymal stem cells attenuate amyloid β-induced memory impairment and apoptosis by inhibiting neuronal cell death. Curr Alzheimer Res. 2010 Sep;7(6):540-8.
  • Lee H, Bae JS, Jin HK. Human umbilical cord blood-derived mesenchymal stem cells improve neurological abnormalities of Niemann-Pick type C mouse by modulation of neuroinflammatory condition. J Vet Med Sci. 2010 Jun;72(6):709-17.
  • Bae JS, Carter JE, Jin HK. Adipose tissue-derived stem cells rescue Purkinje neurons and alleviate inflammatory responses in Niemann-Pick disease type C mice. Cell Tissue Res. 2010 May;340(2):357-69.
  • Lee H, Lee JK, Min WK, Bae JH, He X, Schuchman EH, Bae JS, Jin HK. Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-Pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing sphingosine-1-phosphate. Stem Cells. 2010 Apr;28(4):821-31.
  • Lee JK, Jin HK, Endo S, Schuchman EH, Carter JE, Bae JS. Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses. Stem Cells. 2010 Feb;28(2):329-43.
2009
  • Jin HK, Bae JS, Furuya S, Carter JE. Amyloid beta-derived neuroplasticity in bone marrow-derived mesenchymal stem cells is mediated by NPY and 5-HT2B receptors via ERK1/2 signalling pathways. Cell Prolif. 2009 Oct;42(5):571-86.
  • Lee JK, Jin HK, Bae JS. Bone marrow-derived mesenchymal stem cells reduce brain amyloid-beta deposition and accelerate the activation of microglia in an acutely induced Alzheimer's disease mouse model. Neurosci Lett. 2009 Jan 30;450(2):136-41.
2008
  • Jin HK, Bae JS. Nano fluorescent particles for high efficient mesenchymal stem cell labeling not neural stem cell. Lab Anim Res. 2008 24(2): 217-220.
  • Bae JS, Jin HK. Induction of BDNF expression by intracerebral transplantation of adipose tissue derived-stem cells in Niemann-Pick Type C mice. Lab Anim Res. 2008 24(2): 221-225.
2007
  • Bae JS, Han HS, Youn DH, Carter JE, Modo M, Schuchman EH, Jin HK. Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration. Stem Cells. 2007 May;25(5):1307-16.