Research InterestsNeurodegenerative diseases are defined as hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. Disruption of brain function induced by neurodegeneration have become major public health concerns. The work in our lab is focused on the understanding of the fundamental mechanism that underlie neurodegenerative disorders and developing therapeutic strategies for their treatment. Especially, we are interested in the relationship between brain dysfunction and systemic microenvironment such as blood and bone marrow, in Alzheimer's disease, Niemann-Pick type C disease and age-related neurodegeneration. To investigate this, we use in vitro and in vivo experimental models of neurodegeneration, as well as human samples, such as plasma, fibroblast and post-mortem brain tissue derived from patients, to unravel the pathogenesis of disease. We believe that elucidating the fundamental mechanisms of neurodegenration in experimental models will provide us with important clues for understanding the neurodegenerative process in neurodegenerative conditions and thus open new therapeutic avenues for disabling, currently incurable, neurological diseases.