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2023년 8월 31일 목요일 저널클럽 공지입니다.

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발표자 : 한완희

저널제목 : Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice

저널정보 : Nat Commun. 2023 Jul 13;14(1):4162

저널내용 : Receptor tyrosine kinase(RTK) 중 하나인 AXL가 Brown adipocyte에서 발현되고, Insulin signaling을 통한 PI3K-AKT-Foxo1 pathway를 조절하여, Brown adipocyte의 thermogenesis를 조절한다는 내용의 논문입니다.

발표자 : Chowdhury Md Riad

저널제목 : Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis

저널정보 : Journal of Neuroinflammation (2022) 19:52

저널내용 : In this article, the authors investigated the cellular basis of the Adenosine A2A receptor (A2AR) as a potential pharmacological target to control EAE pathogenesis. They found the specific upregulation of A2AR in the CP associated with enhanced CP gateway activity during EAE.  Furthermore, the KW6002 treatment at days 8–12 or 8–14 post-immunization reduced T cell trafficking across the CP and attenuated EAE pathology.  Also, activation of A2AR in the cultured epithelium by A2AR overexpression or CGS21680 treatment increased the permeability of the CP epithelium and facilitated lymphocytes migration.

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